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细胞增殖的控制
发布时间:2013-11-15 点击次数:572次

细胞增殖的控制

 

   细胞能否进入周期受环境信号的调控.细胞密度低使得细胞周边不受约束,细胞可以任意铺展时,促有丝分裂生长因子,如表皮生长因子(EGF),成纤维细胞生长因子(FGF),或血小板衍生的生长因子(PDGF)欧冠联赛下注app可与细胞表面受体相互作用,从而刺激细胞进入细胞周期.高细胞密度则能抑制正常细胞增殖,但不能抑制转化细胞增殖,细胞互相接触可导致增殖抑制,细胞拥挤和伸展受限导致的细胞形状改变使抑制作用进一步加强.

   XIBAONEIZHENGHUOHUAYINZIHEFUHUOHUAYINZIDIAOKONGZHEXIBAODEZENGZHI.DANGBAONEIQULINSUANHUADESHOUTIYUSHENGZHANGYINZIJIEHEHOU,HUOHUAXINHAOZHUANDAOXITONG,SHIZHENGHUOHUAYINZIRUXIBAOZHOUQISUSHANGDIAOBIAODA,YITUIDONGXIBAOZHOUQIJINXING[Planas-Silva and Weinberg,1997,Reed 2003];FUHUOHUAYINZI,RUp53[Sager 1992,Mcllwrath et al.,1994].P16[Russo et al.,1998]HUORbJIYINDECHANWU[Sager 1992],ZAIXIBAOZHOUQIXIANZHIDIANHUOJIANYANDIANZUZHIXIBAOZHOUQIJINCHENG.TONGGUOXIBAOMOSHOUTIHEXINHAOCHUANDAOTONGLUSHIXIBAOWAIDEDIAOKONGCHENGFEN,BAOKUOZHENGHUOHUAYINZIRUPDGF,FUHUOHUAYINZIRUTGF-β,YUXIBAONEIXIAOYINGCHENGFENXIANG,CIGUOCHENGCHANGSHEJIDANBAIZHILINSUANHUAHEDIERXINSHI,RUCamp,Ca2+HEERXIANJIGANYOUDECANYU[Alberts et al.,2002]DUIZHONGLIUXIBAODEAIJIYINHEYIAIJIYINDEYANJIUBIAOMING,SHANGSHUDIAOKONGXIBAOZENGZHIDEXUDUOBUZHOUQUEYOUZHENGJU,ZHEIYIJIEGUOYOUZHUYULINCHUANGSHANGXUNZHAOYOUXIAODIAOKONGZHONGLIUXIBAOZENGZHIDEFANGFA,ERYOUCIDAILAIDEZHIJIEYICHUSHINENGJIAOHAODIJIESHIWEISHENMESHENGZHANGYINZINENGDIAOJIEPEIYANGXIBAODEZENGZHI[Jenkins,1992],ZHEIXIEYANJIUYEYOUZHUYUJIANDINGZENGQIANGXIBAOZENGZHIDEJIYIN,QIZHONGYOUXIEJIYINKEYONGYUJIANLIWUXIANZENGZHIXIBAOXI.

                 
   
   


   


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